Gerrard, 34, will join the Los Angeles Galaxy in July after almost 17 years at his home-town club and following a 3-1 loss to Crystal Palace, he paid an emotional tribute to Liverpool's fans.
"It felt very strange. I've been dreading this moment. I'm going to miss it so much," Gerrard told the crowd at a sunny, sold-out Anfield.
"I've loved every minute. I'm absolutely devastated I'm never going to play in front of these supporters again."
"I would like to thank all my team-mates, all the ex-players. They've made me the player I am today.
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"I'll save the last thanks to the most important people at the football club. These supporters stand out more than anyone."
He was then interrupted by cheers and applause from the fans, before continuing: "Before I go, before the tears come, I've played in front of most supporters around the world, but let me tell you, you're the best."
He was also presented with a keepsake by former Liverpool manager Gerard Houllier, who handed Gerrard his debut against Blackburn Rovers in November 1998.
Liverpool took a 26th-minute lead through Adam Lallana, but Jason Puncheon equalised with a free-kick shortly before half-time and second-half goals from substitutes Wilfried Zaha and Glenn Murray gave Palace victory.