Ghosal fought back to beat his Colombian rival 11-9, 8-11, 8-11, 11-9, 11-5 in the opening round of the USD 100,000 men's event yesterday.
The world number 21 from India had also defeated Rodriguez in Bogota last year.
The unseeded Ghosal plays sixth seed Karim Abdel Gawad of Egypt later today.
In the USD 70,000 women's event, Joshna Chinappa entered the quarterfinals with a 8-11, 11-8, 11-4, 11-7 win over Egyptian qualifier, while teammate Dipika Pallikal lost to third seed, another Egyptian Nouran Gohar, in straight games.
Chinappa is the second Indian to break the top-10 barrier after Pallikal, who is currently ranked 19th.