The 53-year-old filmmaker gave a tough response to a Twitter user, who is unhappy about the female version of "Ghostbusters" franchise.
"You've been ranting at me and my cast for months with misogyny and insults. So go f*** yourself. Goodnight. #enough" Feig tweeted.
"Then you should embrace a new generation getting their own version. GB is a positive force. Your negativity isn't," he continued.
The reboot will star Melissa McCarthy, Kristen Wiig, Kate McKinnon and Leslie Jones as the ghost-fighting troupe, and Chris Hemsworth as their receptionist.
The film is slated for July, 2016 release.