The artist was best known for his monumental sculptures of Nubian wrestlers inspired by the pictures taken in Sudan by the controversial German photographer Leni Riefenstahl.
Sow's series of striking bronzes of muscular African men -- "The Maasai", "The Zulus" and "The Fulani" -- were widely exhibited in France and at the prestigious Documenta festival in Germany and the Venice Biennale.
"The fact that his works were shown all over the world proved that he was a giant of culture. It is a real loss," said Senegal's Culture Minister Mbagnick Ndiaye.
Yet his 1999 retrospective on the Pont des Arts next to the Louvre in Paris attracted an estimated three million visitors.
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A part of his dramatic installation on the 1876 Battle of Little Bighorn in which Native Americans led by Crazy Horse defeated General George Custer's 7th Cavalry, was later shown at the Whitney Museum in New York.
Critics said the key to his success was his intimate knowledge of human anatomy.
"I could be blindfolded and still make a human body from head to toe," he once said.
"He has taken with him all the dreams and projects that his body was too tired to finish," she said.