The zoo says Yun Zi was crated up and driven to Los Angeles on Thursday in preparation for the flight. His keeper and a veterinarian will accompany him.
The zoo's pandas are on loan from the Chinese government, which decides where zoo-born offspring go after they turn 3. Yun Zi turned 4 in August.
The zoo prepared Yun Zi for the trip by making the special bread he'll eat in China instead of the kibble used in San Diego. He's also been fattened up to deal with the cooler temperatures of the mountains where he'll live.