Lopez, 46, and her then-partner Ben Affleck teamed up for the poorly-received film, which has become a punchline for flops, reported Contactmusic.
In a new interview, Lopez said her positive outlook has always helped steer her back to success when thinks looked a little bleak for her career.
"I never thought of it as, 'Oh, this is terrible! My career's over!' I just never thought that. I just knew that that movie didn't work and that's all it was," she said.
"(I'm like), 'That relationship didn't work and that's all it was'," she added.
"It wasn't going to end me, personally or professionally.