The autorickshaw driver was also injured in the accident that took place near a traffic junction in Jyoti Nagar around 6 am, police said.
The deceased has been identified as Aarti, a student of a government school in Loni.
"The deceased and her relatives were heading towards north-east Delhi's Krishna Nagar area in an autorickshaw. On getting hit by the speeding truck, the autorickshaw flew several metres away and crashed onto a pavement," a police officer said.
"Locals rescued the passengers and called up the police following which they were rushed to GTB hospital, where Aarti was declared brought dead," the officer added.