After tweeting an apology to Zendaya, Rancic, 40, apologised again to the 18-year-old actress during a brief E! News segment, reported Ace Showbiz.
Rancic's apology came after her 'Fashion Police' co-host Kelly Osbourne threatened to quit the show due to the debacle.
Giuliana said, "I'd really like to address something that's weighing very heavy on my heart. I want to apologise for a comment that I made on last night's 'Fashion Police' about Zendaya's hair. As you know, 'Fashion Police' is a show that pokes fun at celebrities in good spirit, but I do understand that something I said last night did cross the line.
"Therefore, I want to say to Zendaya, and anyone else out there that I've hurt, that I'm so so sincerely sorry.
"This really has been a learning experience for me. I've learned a lot today and this incident has taught me to be a lot more aware of cliches and stereotypes, and how much damage they can do. And that I am responsible, as we all are, to not perpetuate them further," she further added.