Crowds gathered to watch the demolition of the triple tower block at Petershill Drive in the north of the largest city in Scotland.
Built in the mid-1960s to tackle the city's housing crisis, the flats once provided accommodation for almost 5,000 people.
The demolition programme, which changes the city's skyline, is part of Glasgow Housing Association's renewal plan.
There were eight tower blocks in total and when they were built, at 292ft (89m), they were the tallest residential structures in Europe.
Initially they were regarded as the answer to Glasgow's housing problem but in recent years have become rundown and vandalised, and stand largely empty, the BBC reported.
Alex McGuire, from Glasgow Housing Association, said: "The Red Road flats were popular in their day and are known around the world, but their time has come to an end.
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"We're pleased the demolition of the first of the Red Road blocks went according to plan."
About 275 kilogrammes of explosives were used to bring down the triple block.
Due to the unique steel-frame structure of the flats, the bottom storeys remained - as planned - undisturbed after the blowdown. These will be demolished using machines.
About 2,000 people were temporarily removed from their homes with many of the local residents staying with family or friends or at the evacuation centre.
The clear-up operation will take several months to complete.
In recent years the flats had been home to refugees from many countries. In March 2010, three Russian asylum seekers who had been living in the flats jumped to their deaths from one of the towers in Petershill Drive.
The remaining seven multi-storeys in the area are due to be demolished by 2017, the report said.