But the globetrotting travel writer is now convinced the most exciting place to go is nowhere at all.
In his new book "The Art of Stillness," the British-born, California-raised son of Indian parents preaches sitting quietly in one place as an antidote to our constantly- connected, multi-tasking, airport-hopping lifestyles.
Iyer, 57, a Time Magazine journalist, shot to international fame with his 2000 book "The Global Soul," which chronicled the emergence of a new breed he dubbed "transnationals" people who all but live in airports, have addresses on different continents and carry several passports and multiple currencies in their pockets at all times.
"It was gradual. I noticed I had 1.5 million miles on United Airlines alone, so I thought, 'I've got plenty of movement in my life,'" he said in an interview in Rio de Janeiro, where he spoke at a TED conference last month. "I need stillness."
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While this chosen isolation might seem counterintuitive for someone who still makes his living as a travel writer - Iyer acknowledged that being hard to reach has infuriated many an editor over the years -- he insisted it enriches both his life and his work by giving him the time and the space necessary to process, digest and reflect on experience.
"I can feel inside myself that spending time very quietly is like the construction of a house that then you can go and inhabit, rather than always running on quicksand, which I feel that more and more of us are doing now."
A heartfelt manifesto to the benefits of ditching the cellphone and snipping up the frequent flier card, "The Art of Stillness" is anything but a self-help book or how-to guide for achieving inner peace.