Construction of the plant -- which will have annual capacity of 150,000 vehicles -- will start in June, GM said in a statement.
The factory, the first in China dedicated to making Cadillacs, will come under Shanghai GM, a joint venture with China's SAIC Motor.
"Shanghai GM has received the NDRC's (National Development and Reform Commission's) approval to build a Cadillac plant," the statement said.
Analysts say GM is a laggard in the segment, one of China's fastest growing and most profitable given rising incomes in the country.
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"GM needs to build a relatively high-end brand in China in order to improve its overall product line," said Jia Xinguang, managing director of industry group the China Automobile Dealers Association.
"It also sees the growth potential in China's high-end car market, so the establishment of the plant will allow it to enter the market and win a bigger share," he told AFP.
China's market for what the industry calls "premium" cars -- costing from USD 32,000 to USD 190,000 -- was 1.25 million vehicles last year, second only to the United States, according to consultancy McKinsey.
Premium car sales in China grew at an average 36 per cent a year in the last decade, though that would slow to an annual 12 percent through 2020, McKinsey said in a report in March.
GM launched a Cadillac sedan, the XTS, in China earlier this year as it seeks to make inroads into the sector. That vehicle, priced from USD 56,800 to USD 92,500, is produced in China.
In the first four months of this year, GM sold 11,571 Cadillacs in China, according to figures previously released by the company.
"Our longer-term goal is to take Cadillac's share of the luxury car market to 10 per cent by 2020," GM China president Bob Socia said.
Speaking on the sidelines of the Shanghai auto show, Socia also played down concerns of production overcapacity in China, saying GM plans to add four more plants by 2015 to meet demand.