50-year-old Ram Sanehi and his wife Kusum (48) died on the spot near Gausana village of Jamuna Paar area, police said.
Their 10-year-old grand daughter Anuska was rushed to Agra Medical college and is reported to in serious condition, police said.
They were residents of Prakash Nagar area here and were going to Bhainsara area when the car hit them, police said, adding that driver of the car fled from the spot.