The vote in parliament, expected after midnight, will levy around one billion euros (USD 1.07 billion) in extra taxes on cars, fixed telephone service, pay TV, fuel, tobacco, coffee, beer and other items.
Public spending on salaries and pensions will also be cut by 5.7 billion euros next year.
Thousands of Greeks took part in union demonstrations and a general strike this week against the new cuts, but the leftist government majority is expected to approve the budget despite the misgivings of many of its lawmakers.
Greece hopes that a deal will persuade the European Central Bank (ECB) to include Greek sovereign debt in its asset purchase programme, known as quantitative easing, or QE.
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Without access to QE, the country will not be able to make a planned return to debt markets by early 2018, according to the Greek finance ministry.
Last week, eurozone lenders approved short-term relief measures to help Greece manage repayment on its huge public debt, which will reach 315 billion euros this year, according to the latest EU data.
Hardline EU states also want Greece to run a primary surplus, after debt servicing, of 3.5 per cent of gross domestic product (GDP), beyond 2018.
Athens has flatly refused to consider further austerity measures beyond 2018.
Tsipras on Thursday made a surprise move, announcing a one-off payout to 1.6 million low-tier pensioners, and a sales tax break for islands sheltering thousands of migrants.
The European Commission said it was "not made aware of all the details of the announcement before they were made" and would need to study the 617-million-euro package "before commenting any further or acting further."
"Europe owes a debt to (these islanders), the Greek state owes them its support," Tsipras said in his announcement, with officials noting that the money would come out of 1.0 billion euros of tax surplus raised in 2016.
Finance Minister Euclid Tsakalotos today said Greece could manage a primary surplus of 2.5 per cent, and dedicate a further 1.0 percent to tax breaks for small and medium businesses.
Tsakalotos today also praised Eurogroup chief Jeroen Dijsselbloem, a frequent critic of the Tsipras administration, as a man of principle.
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