Grunberg has been cast as a man struggling with addiction in rehab while trying to rebuild his relationship with his children, reported The Wrap.
An air date for his guest appearance has not yet been announced by CBS.
The 48-year-old actor most famously played the telepathic lawman Matt Parkman in 'Heroes' for four years.
Grunberg also had a memorable appearance in 'Lost' as the doomed Flight 815 pilot Seth Norris.