While Desai has been put in charge of the Mumbai city, Tawde will look after the suburbs.
Chief Minister Devendra Fadnavis named Guardian Ministers for all the 36 districts in the State, where Sena-BJP alliance is in power.
Some senior BJP and Sena Ministers have been made in- charge of two districts.
The total strength of the Council of Ministers headed by Fadnavis is 30.
Guardian Ministers are appointed to look after the development plans and related affairs of each district.
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Senior BJP leader Eknath Khadse, who handles Revenue and Agriculture portfolios, will look after Jalgaon and Buldhana while Cooperation Minister Chandrakant Patil will handle Sangli and Kolhapur.
Finance Minister Sudhir Mungantiwar has been given charge of Wardha and Chandrapur while Rural Development Minister Pankaja Munde will look after Latur and Beed.
Public Undertakings Minister Eknath Shinde (Shiv Sena) will be in charge of Thane and Tribal Welfare Minister Vishnu Sawra (BJP) will look after the newly created Palghar district.
The others include Minister of State for Home Ram Shinde (Ahmednagar), Water Resources Minister Girish Mahajan (Nashik and Nandurbar), Parliamentary Affairs Minister Girish Bapat (Pune), Minister of State for Water Resources Vijay Shivtare (Satara).
Minister of State for Transport Vijay Deshmukh (Solapur), Minister of State for Industries Pravin Mote (Amravati), Minister of State for Home (urban) Ranjit Patil (Akola), MoS for Revenue Sanjay Rathod (Yavatmal).