The filmmaker has reportedly delayed the long-gestating project until after he completes work and promotion on "The Shape of Water", which is due out on December 8, reported Deadline.
Del Toro signed on to direct the remake over a year and a half ago.
The original plan was to start production on "Fantastic Voyage" remake next spring for a holiday 2019 release.
But with the "Shape of Water" commitments and the potential awards season activity, the project will now resume next year, pushing the release to 2020.