The victims were heading to Ahmedabad from Surendranagar. Three persons were killed on the spot, while two died on the way to hospital, police said.
The deceased were identified as Lalji Darji, Abhaydan Gadhvi, Ranjit Vaghela, Ramdan Gadhvi and Mahesh Gadhvi, all residents of Bopal in Ahmedabad.
They were returning after attending an event in Kutch.
The injured were taken to Ahmedabad civil hospital.
Police said they had lodged a complaint against the truck driver, who fled the spot after the accident.