Police Sgt. Rudy Flores said those believed to be down included the shooter. He did not elaborate on the extent of their wounds.
Flores said numerous witnesses called to report that the shooting began with a man on a street corner firing shots shooting at vehicles, including a bus.
The gunfire took place about 5 kilometres from where President Barack Obama was attending a fundraiser today afternoon.
Secret Service spokesman Max Milien said the agency was aware of the shooting and it's not affecting the president's event.