The attack last night in the village of Santa Rosa was the latest violent episode in a country that has the world's highest murder rate.
Police told local media unidentified gunmen drove up in a vehicle, got out and opened fire on the soccer players with automatic weapons.
The Observatory of Violence, a monitoring group at the National Autonomous University of Honduras, said there were 111 attacks last year in which in three or more people were killed.
A proliferation of violent street gangs and the infiltration of Mexican drug cartels have contributed to the soaring crime, analysts say.
Earlier this month, the government started putting soldiers on public transports to defend them against attacks.