Trump, who is likely to advance his "America First" agenda with world leaders at this year's WEF, would be the first sitting US president to attend the high-profile summit since Bill Clinton in 2000.
The World Economic Forum Annual Meeting 2018 would be held from January 23 to 26 in Davos-Klosters, Switzerland, under the theme 'Creating a Shared Future in a Fractured World'.
Trump's itinerary has not been announced yet.
In a statement, the White House said the delegation would be led by the Treasury Secretary Steven Mnuchin.
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Other members of the delegation are Robert Lighthizer, United States Trade Representative; Thomas Bossert, presidential adviser for Homeland Security and Counterterrorism; Trump's son-in-law Jared Kushner, USAID Administrator Mark Green; and Scott Gottlieb, Commissioner of Food and Drugs.
Mnuchin told reporters at the White House news conference he expects president Trump will talk about trade: reciprocal, free and fair trade.
"We have obviously been very clear with the Chinese on the issue that we have with the trade deficit, making sure that US companies can compete fairly.
Later in a statement, White House Press Secretary Sarah Sanders said the official delegation would also include Chief of Staff John Kelly, National Security Adviser H R McMaster, and Director of the National Economic Council Gary Cohn.