Hamilton said his Mercedes, which took him to pole position at the Formula One season-opener but then lasted just a few laps of the race, was the strongest he had brought to tropical Malaysia's Sepang circuit.
"I've had some good results here but obviously I haven't won here. So that's been the challenge every time I come," said Hamilton, who was second in 2007 and finished third last year and the year before.
The 2008 world champion was the prime performer in pre-season and he was runaway favourite to win in Australia after snatching a thrilling pole position at Melbourne's Albert Park.
But a misfiring cylinder ended Hamilton's race within minutes as Mercedes team-mate Nico Rosberg flew to a commanding win 25 seconds ahead of his nearest challenger.
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"Reliability's going to be put to the real test this weekend. Because it's so hot, the engine's going to be on the absolute limit," he added.
"I really don't know how big the advantage (of Mercedes) is going to be. I'm sure people will have made some improvements this weekend so maybe it'll be a bit closer... Everyone's stepping up and everyone's pushing."
Rosberg now finds himself in the novel position of leading the championship standings, and he said he was more than happy with Formula One's new era following a raft of technical changes.
Red Bull's Sebastian Vettel, who won his fourth straight world title last year at a canter, also had problems in Melbourne and retired early.