Lewis Hamilton will seek a fifth win in six visits to Texas this weekend and hope for further Ferrari misfortune as he bids to clinch his fourth world title at the United States Grand Prix.
The Briton leads nearest rival Sebastian Vettel by 59 points with four races remaining and will take this year's crown if he can outscore him by 16 points.
In short, that means that if Hamilton wins, Vettel must finish in the top five to keep his own challenge alive - a seemingly straightforward prospect if he and Ferrari can avoid the mishaps that have afflicted them in the last four races.
That embarrassing exit followed a crash with his Ferrari team-mate Kimi Raikkonen in Singapore and an engine problem in Malaysia - incidents that allowed Hamilton to capitalise for Mercedes by grabbing three wins in four races.
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Hamilton now has 306 points and Vettel, the only other man to have won at Austin's Circuit of the Americas, has 247.
Mercedes boss Toto Wolff made clear that he would not stop him.
"The more you try to limit him - put him in a box - the more detrimental it will be for his performance," he said.
With temperatures forecast to continue at around 30 degrees Celsius it may be that conditions favour Ferrari's faster, but less reliable car at a track that Hamilton, chasing a sixth overall United States GP win, relishes.
Only Michael Schumacher, with seven titles, and Juan- Manuel Fangio, with five, have more and a fourth Hamilton triumph would make him the most successful British driver.
- 'Take nothing for granted' -
But as Ferrari seek to preserve their challenge with improved reliability, Hamilton's main threat may come from Red Bull's Max Verstappen, who won in Malaysia three weeks ago, or Daniel Ricciardo, like Hamilton a man very at home in America.
"The team is operating at an incredibly high level in every area and continuing to develop," he said. "But Lewis has driven brilliantly this year and, since the summer break in particular, he has been on another level.
"It has been impressive to watch him extracting everything from the car and working with the team to solve problems and improve even further.
"But we can take nothing for granted... We have seen a strong points swing in our favour in both championships -- good fortune has played its part, of course - and we have put ourselves in the right position to make the most of the opportunities.
For Fernando Alonso, it will be a chance to thank the American fans for their support of him when he took part in the Indianapolis 500 - and he plans to switch helmets and use the one he wore at 'The Brickyard' in May.
The weekend will also see New Zealand's Le Mans 24-Hours winner Brendan Hartley, a former Red Bull squad junior and reserve driver, make his debut with Toro Rosso alongside returning Daniil Kvyat.
He succeeds Carlos Sainz who has been released to join Renault.
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