The attack took place on a school in Orangi area of the city and injured were sent to a local hospital for treatment, police said.
Earlier, on March 30, in a similar hand grenade attack on a school in Baldia town, the principal, who belonged to a political party was killed while four students were injured.
Similarly, a philanthropist and social activist Abdul Waheed was shot dead on May 13 by unidentified men at his medical store in the area.