Harika, playing with white against Russia's Olga Girya, had to dig deep into her reservoir to pull off the much-needed draw to win the title, her maiden career GP title.
Harika finished on 7 points in the round robin tournament featuring the world's top 12 players to be crowned the champion.
Other India Grand Master Koneru Humpy too rounded off her campaign with a victory to also finish on 7 points. Harika, however, was declared winner for finishing with a better tie-break record in the tournament.
"I was in a winning position," she said shortly after the win. "But I felt the pressure and couldn't play my best game. I am extremely happy as this is my first Grand Prix title."
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Olga kept her at the table for 62 tense moves before finally accepting the draw. The triumph adds a bounty to her points tally and should see her quality for the World Championships later this year.
Harika couldn't help but get emotional as the national anthem was played at the Chengdu arena to celebrate her victory. "I felt numb and exhilarated as I listened to the national anthem."