However, she could not end the day blemish free and lost out to Bacrot Etienne in her second game of the day.
Starting with white pieces in her round seven game against the former World Champion Karpov of Russia with an ELO rating of 2628, Harika, the lone Indian player at tournament, began on an attacking note and matched her opponent move by move.
She, however, could not capitalize on her good start and Karpov brought all his experience into play and staved off a strong challenge to escape with a draw in the game which lasted for 51 moves.
However, the Frenchman who is the highest rated player in the tournament with an ELO rating of 2692 proved to be the better player on the day and walked away with a hard fought victory.
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Talking about her performance during the day, Harika said, "I had a great chance to win the first game. I was in better position in the middle and was slightly better than him all through the game. But unfortunately, I could convert my chances and had to settle for a draw.
Harika, who is currently fifth on the points table will now take on the Spaniard Sabrina Vega Gutierrez and local lad Matthieu Cornette on day five.