Playing for Team Shandong, she beat Ni Shiqun of Team Tianjing to put her side in a sting position after two days.
Harika comfortably drew her opening game against Qi Guo of Team Jiangsu.
"I started today with black and immediately guided the game to a complicated position. My opponent made a few mistakes and I pounced on them to extract a victory in 26 moves. I am very happy with the way I played," she said, shortly after completing the win.
The Chinese Chess League is an annual elite tournament, comprising 12 teams. All of China's top players and a number of foreign players have assembled in Jiaxing for this event.
The entire league is played from April to December, lasting 22 rounds in six 3-4 day sessions. The current leg will end on July 26. Each match is played over five boards, with women playing on two of them.