The cuts amount to about 5 per cent of the company's workforce. The Milwaukee Journal Sentinel reports that about 70 contractors also will be affected.
The company says it will incur up to USD 25 million in employee separation and reorganization costs as it cuts production and reduces workers.
Harley-Davison has 1,024 salaried employees at its Milwaukee headquarters and 3,246 salaried employees worldwide.
The company has not disclosed where the job cuts will take place.