Described by Obama as "fearless", 51-year-old Harris is headed for a "landslide win" in the US Senate elections from California.
"It is going to be a landslide," M R Rangaswami, a Silicon Valley-based investor, entrepreneur and philanthropist, said ahead of November 8 election described as a momentous occasion for the Indian-American community.
Considered to be protege of Obama, she is expected to be a fierce advocate of India US relationship.
Harris has already got the backing of Obama and Vice President Joe Biden to be the state's next Senator, brightening her chances to become the first from the community ever to be a member of the Upper House.
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She heads into the US Senate election with a considerable lead over fellow Democrat Loretta Sanchez, whose plan to coalesce Republicans and Latinos behind her has not materialised, according to a new poll.
"Kalama Harris knows, you got to be fearless against special interest," Obama said in a latest advertisement for Harris being run across California.
"The kind of support she has got in the nation including the President, I think, she would be very well received by the DC crowd. She has got that national stature," Rangaswami noted.
On India-US relationship, Harris came out with flying colours when she was grilled by a group of prominent Indian- Americans in the Silicon Valley some six months ago.
"We had a very constructive dialogue. I think, as a result of the meeting she is closer to the issues that impact Indian Americans and India," Rangaswami said.
Rangaswami said she would be quite sensitive to the issues related to the community including immigration and India.
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