Citing his recent rhetoric, in particular the statement against the parents of Muslim-American soldier who was killed in a terrorist attack in Iraq, the Harvard Republican Club in a statement asked party leaders to withdraw their support from Trump.
"For the first time in 128 years, we, the oldest College Republicans chapter in the nation, will not be endorsing the Republican nominee," the club said in a statement.
Trump, they alleged, holds views that are antithetical to values not only as Republicans, but as Americans as well.
"If enacted, Trump's platform would endanger our security both at home and abroad. Domestically, his protectionist trade policies and draconian immigration restrictions would enlarge our federal deficit, raise prices for consumers, and throw our economy back into recession," the young Republicans feared.
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Trump's global outlook, steeped in isolationism, is considerably out-of-step with the traditional Republican stance as well, they argued.
"His authoritarian tendencies and flirtations with fascism are unparallelled in the history of our democracy. He hopes to divide us by race, by class, and by religion, instilling enough fear and anxiety to propel himself to the White House.
"He is looking to pit neighbour against neighbour, friend against friend, American against American. We will not stand for this vitriolic rhetoric that is poisoning our country and our children," the club said.
The Harvard Republican Club said the former US President Ronald Reagan would have been ashamed of Trump.