The 41-year-old actor-designer, who as per Weinstein stood "100 percent" behind him in wake of the scandal, said she is heartbroken for the women who have suffered at the hands of her husband.
"My heart breaks for all the women who have suffered tremendous pain because of these unforgivable actions. I have chosen to leave my husband.
"Caring for my young children is my first priority and I ask the media for privacy at this time," Chapman said in a statement to People magazine.
"I support her decision, I am in counselling and perhaps, when I am better, we can rebuild. Over the last week, there has been a lot of pain for my family that I take responsibility for.
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"I sat down with my wife Georgina, who I love more than anything, and we discussed what was best for our family. We discussed the possibility of a separation and I encouraged her to do what was in her heart. I understand, I love her and I love our children and hopefully, when I am better, I will be in their lives again," the producer said in a statement released by his spokesperson.
Post the controversy, Weinstein was sacked from The Weinstein Company (TWC) as co-chairman.
Big Hollywood names such as Meryl Streep, George Clooney, Jennifer Lawrence and Judi Dench have joined the growing chorus against the producer, criticising his behaviour as "indefensible" and "horrifying".
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