The private sector bank had a net profit of Rs 2,791 crore in the October-December quarter of last fiscal.
Its total income rose to Rs 18,282 crore during the December quarter, from Rs 14,931 crore in the year-ago period.
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Net interest income grew 24% to Rs 7,068.5 crore during the quarter, driven by average assets growth of 28.2% and a net interest margin of 4.3%.
The net non-performing assets (NPAs) as a percentage of total loans rose marginally to 0.29% at the end of December, from 0.26% in same period last year.
Other income, which includes revenues from fees and commission, foreign exchange and derivatives, grew 13.3% to Rs 2,872 crore.
Total deposits as of December, 2015 were over Rs 5.23 lakh crore, an increase of 26.5% over December 2014.
Advances as of December 2015 were over Rs 4.36 lakh crore, a growth of 25.7% over December 2014.
Total balance sheet size as of December was over Rs 6.87 lakh crore, as against over Rs 5.34 lakh crore at the end of December 2014.
Shares of HDFC Bank were trading at Rs 1,044.60, up 1.39%, on the BSE.