The country's second-largest private sector lender had reported a net profit of Rs 2,326.52 crore in corresponding quarter of 2013-14.
"After providing Rs 1,338.4 for taxation, the bank earned a net profit of Rs 2,806.9 crore for the quarter ended March 31, 2015, an increase of 20.6 per cent over the quarter ended March 31, 2014," HDFC Bank said in a filing to the BSE.
The bank's total income increased from Rs 12,789.98 crore in the fourth quarter of 2013-14 to Rs 15,570.13 crore in the corresponding quarter of 2014-15, it added.
The growth in net interest income (NII) was driven by average asset growth of 21.2 per cent and 4.4 per cent net interest margin for the quarter.
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On asset quality front, the bank's net non performing assets (NPAs) or bad loans were trimmed to 0.2 per cent of the total advances during the quarter, from 0.3 per cent in the year-ago period.
Gross NPAs also came down to 0.9 per cent in the last quarter, from 1 cent in the year-ago period.
The total full year income increased from Rs 49,055.18 crore for the year ended March 2014 to Rs 57,466.25 crore for the year ended March 2015, it said.
HDFC Bank shares closed almost flat at Rs 1,011 apiece on the BSE, marginally down by 0.39 per cent from previous close.