The bank had earned Rs 2,381.5 crore profit in the same July-September quarter of the last fiscal, 2014-15.
The banks total income for the September quarter this fiscal was Rs 17,324.3 crore, up from Rs 13,894.7 crore in the year-ago period.
"After providing Rs 1,492.2 crore for taxation, the Bank earned a net profit of Rs 2,869.5 crore, an increase of 20.5 per cent over the quarter ended September 30, 2014," the HDFC Bank said in a regulatory filing.
The net NPAs were at 0.2 per cent of net advances.
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Net interest income (interest earned less interest expended) for the quarter grew by 21.2 per cent to Rs 6,680.9 crore driven by average assets growth of 29 per cent and a net interest margin for the quarter of 4.2 per cent, it added.
It further said net revenues increased by 22.2 per cent to Rs 9,232.7 crore in the reporting quarter.
Other income (non-interest revenue) at Rs 2,551.8 crore was 27.6 per cent of the net revenues for the quarter ended September 2015 and grew by 24.7 per cent over 2,047.1 crore in the corresponding period last fiscal.
The Bank's total capital adequacy ratio (CAR) as per Basel III guidelines, was at 15.5 per cent as against a regulatory requirement of 9 per cent.
For the half year ended September 2015, the bank earned a total income of Rs 33,827.3 crore as against Rs 26,965.4 crore in the corresponding period of last fiscal.
At September end, the bank had distribution network of 4,227 branches and 11,686 ATMs.
The HDFC stock was trading at Rs 1,092.65, 0.24 per cent, on the BSE.