The latest victim of the H1N1 virus in the city was a five-month-old baby which succumbed a couple of days ago, taking the death toll in the last three months to seven.
About 20 people are currently undergoing treatment for the infection in different hospitals with half a dozen of them needing ventilator support.
"Swine Flu has become endemic in Pune region. The hospitals have been advised to focus on the elderly with underlying medical conditions and newborns who are more susceptible to the virus," said S T Pardeshi, Acting Chief Medical Officer, Pune Municipal Corporation (PMC).
Health officials said the increase in the Swine flu cases could be due to a widely fluctuating and erratic climate and temperatures characterised by hotter days and colder nights experienced at present in the region.
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Standard precautionary measures have been advised by health officials to prevent active transmission of the virus which include regular washing of hands with soap, water and alcohol based disinfectants and covering nose and mouth with a tissue while coughing and sneezing.
Pune had emerged as epicentre of the dreaded virus when the country's first Swine flu casualty was reported from the city in 2009.
Asked as to whether the virus had undergone a mutation, Pardeshi said the civic authorities had not received any such advisory and maintained that Tamiflu tablets continued to be the mainline treatment for the infection with satisfactory results.