The heart was harvested from a brain dead patient, Vinay Kumar from Aluva in Ernakulam district, and brought here early today by road and transplanted successfully on V K Podiyan from Pathanamthitta district.
Dr P K Jaykumar, who led the 40-member team, attributed the first phase success to team work.
The patient's condition was "satisfactory" and the next 48 hours would be very critical, he said, adding, Podiyan would be monitored closely for six weeks.
Podiyan's wife Omana profusely thanked the donor's family and doctors who performed the transplant.