Although it is too early to say for this outbreak, past outbreaks of similar diseases involved more than just biology.
In the past, weather has played a key role, as have economics, human travel, air conditioning and mosquito control. Even El Nino sneaks into the game.
Scientists say you can't just blame one thing for an outbreak and caution it is too early to link this one to climate change or any single weather event.
"With higher temperatures you have more mosquitoes feeding more frequently and having a greater chance of acquiring infection. And then the virus replicates faster because it's hotter, therefore the mosquitoes can transmit earlier in their life," Reisen said. The thermodynamics of mosquitoes are "driven by temperature."
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The hotspots for this Zika outbreak also have been temperature and drought hotspots recently. Recife, Brazil, the largest city in the Zika-struck region, saw its hottest September-October-November on record, about 1.2 degrees Celsius (2.2 degrees Fahrenheit) above normal, according to NASA data.
Scientists have studied Zika far less than other mosquito-borne diseases, so for guidance they often look at dengue fever or chikungunya, which are transmitted by the same species of mosquito. Dengue infects as many as 400 million people a year, with a quarter of them sick enough to be hospitalised.
Zika was just declared a global public health emergency after being linked to brain deformities in babies in South America.
Several thousand cases of microcephaly have been reported in Brazil since October, although researchers have so far not proven a definitive link to the virus. No vaccine exists for Zika.
That's also about how long it takes a virus to grow in the mosquito gut, making the bug infectious and able to spread the disease. Often the insect will die before it can get a chance to spread the disease.
Warmer air incubates the virus faster in the cold-blooded mosquito. So the insect has more time to be infectious and alive to spread the disease, Scott said.
Warmer temperatures also make the mosquito hungrier, so it takes more "blood meals" and can spread the disease to more people, Scott, Reisen and others said. And warmer temperatures generally increase the mosquito population.
That's not the only role of weather. El Nino, a natural warming of parts of the central Pacific Ocean that changes weather worldwide, usually puts northeastern Brazil into a drought, as it did last year.
Aedes aegypti does well in less-developed regions in droughts, because it lives in areas where poorer people store water in outdoor containers, said Jonathan Patz, director of the global health institute at the University of Wisconsin.
"As with all mosquito-borne viruses, climate is one of many factors that influence Zika transmission," said Andy Monaghan, a scientist who works on public health impacts of climate change at the National Center for Atmospheric Research.