"Hillary Clinton will do anything to gain and hang on to power, anything," corporate leader-turned politician Fiorina said during the GOP undercard presidential debate in Iowa.
"Listen, if my husband did what Bill Clinton did, I would have left him long ago," the 61-year-old said.
Clinton, 68, is eyeing to become the first woman president of the US and is likely to win Democratic Party nomination. A former First Lady, Clinton served as the Secretary of State in the first term of the Barack Obama administration.
"It's called the Clinton way. Both Bill and Hillary practice it, the Clinton way. Say whatever you have to say, do whatever you have to say. Lie as long as you can get away with it. Hillary Clinton cannot be the president of the US," she said.
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During the debate, Fiorina lashed out at Clinton on the 2012 Benghazi attack in Libya, when militants attacked the US diplomatic compound, killing Ambassador J Christopher Stevens.
"That, Mrs Clinton, is what difference it makes," Fiorina said.
While low on her poll numbers, Fiorina said that she can successfully take on Clinton during the presidential election.
"She has escaped prosecution more times than El Chapo, perhaps Sean Penn should interview her," she said adding that Clinton needs to be prosecuted.
"While Mrs Clinton has flown hundreds of thousands of world around the global, I have too..And I know flying is an activity not an accomplishment. While I know that she has held many positions and many titles she has not accomplished much of anything in her life. She has gotten every single foreign policy challenge wrong," Fiorina said.