Hollywood star Leonardo DiCaprio will host the Democratic presidential nominee during the fundraiser.
The show announced that Clinton will make her first late-night talk show appearance since accepting the Democratic nomination last month at the DNC in Philadelphia.
She last visited Kimmel in March and also made an appearance in November.
The 68-year-old former Secretary of State has also made visits to NBC's "The Tonight Show Starring Jimmy Fallon" and CBS' "The Late Show With Stephen Colbert," among other late-night shows.