In an interview to be aired tomorrow on CNN, Bill Clinton, the former US President, said he thought she was "the most gifted person I'd ever met" and that it "would be wrong for me to rob her of the chance to be what I thought she should be."
Hillary, 67, officially launches her 2016 presidential campaign with a big campaign rally from New York today.
If elected, she would be the first woman president of the United States.
"I trust her with my life, and have on more than one occasion," he told CNN, according to excerpts aired today.
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"Whenever I had trouble, she was a rock in our family," said the former US President.
Bill said he would support her in achieving her political goal.
"We were married a very long time when she was always, in effect, deferring to my political career," he said.
"If she wanted to know my opinion, I would tell her, but she had carte blanche to make whatever decisions she wanted, and tell me what I was supposed to do about it," he said.
Bill and Hillary married in 1975, and over the years their relationship has struggled, especially during Bill Clinton's impeachment trial and the affair with White House intern Monica Lewinsky.