Tension ran high in Mehran Samejo village in Ghotki district after a Hindu man, Amar Lal, who was said to be mentally unstable, allegedly desecrated a holy book yesterday.
According to reports, Amar, who has been arrested, was a drug addict and was living in a mosque after converting to Islam a few months ago.
After the incident, local religious leaders along with several agitated people took to streets.
In the attack, one of the youths, Dewan Sateesh Kumar, 17, was killed while another was critically injured, Senior Superintendent of Police (SSP) Masood Ahmed Bangash said.
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Satesh was a businessman.
Local leaders of the Hindu community have demanded protection of their lives and properties in the wake of the tensions.
Bangash said that police with the help of Rangers are trying to diffuse the tense situation.
According to reports, all towns of the Ghotki district remained closed today.
Sindh has the biggest population of Hindus in Pakistan.