Hollande will hold talks with Saudi King Abdullah, but will also meet former Lebanese premier Saad Hariri and Syrian opposition leader Ahmed Jarba in the kingdom, said a member of his entourage.
Crown Prince Salman bin Abdulaziz met Hollande upon his arrival in the capital Riyadh. The French leader is scheduled to meet the king at his Rawdat Khurayim farm, 60 kilometres northeast of the capital.
Four ministers and 30 top figures in French business have accompanied Hollande on the visit.
Hollande's meeting with Hariri, a staunch critic of the Syrian regime, comes amid heightened tensions in Lebanon after the killing of his close aide, ex-minister Mohammad Chatah, in a car bomb on Friday in Beirut.
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Hariri, the son of former premier Rafiq who was also assassinated in a massive car bomb in February 2005, lives outside Lebanon due to security concerns.
The Sunni Muslim leader is also a strong critic of the Iran-backed Shiite Hezbollah movement, which is fighting alongside President Bashar al-Assad's forces in Syria's civil war.
French Foreign Minister Laurent Fabius said Hollande would deliver a "special message" to Hariri reiterating that France is "a friend of the Lebanese and Lebanon, (and) calls for the integrity and independence," of the country.
France "rejects the contagion that some want to impose between the conflict in Syria and Lebanon," he said on the presidential plane.
As for Syria, Hollande will tell Jarba that the participation of the opposition in the proposed peace conference in Switzerland on January 22 is "desirable", according to Fabius.