It said Jayalalithaa suffered a massive cardiac arrest on December 4 while an intensivist was present at the ICU in Apollo Hospitals in Chennai.
"The late Chief Minister Jayalalithaa passed away at 11.30 PM on December 5, 2016," the report said.
Meanwhile, Tamil Nadu Health Secretary J Radhakrishnan told reporters in New Delhi after receiving the report by AIIMS doctors that there "is no basis to the speculation which has been circulated in the media" on Jayalalithaa's treatment.
"It is a very self-explanatory report and we have not held back anything," Radhakrishnan added.
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Meanwhile, the press statement quoting the report said Jayalalithaa was administered resuscitation and provided ECMO (Extracorporeal Membrance Oxygenation) support within an hour.
"Every possible clinical attempt was made to sustain her revival as per prescribed medical protocols," the statement said, quoting Radhakrishnan.
He said a team of doctors, including experts from Apollo and AIIMS, assessed the situation. It was clinically concluded that there was no heart function and also no neurological improvement, denoting futility of life support.
It was also conveyed to the chief secretary, the health secretary and other top government officials, the statement quoted him as saying.
All of them understood the situation and asked the medical team to act as per the standard protocol.
Radhakrishnan said medical practitioners are bound to not reveal details related to patients.
However, "given the need to put at rest needless speculation relating to the circumstances surrounding the hospitalisation, treatment and sad demise of the late Tamil Nadu Chief Minister, the government decided to make public the discharge summary received from Apollo Hospitals and the medical report received from AIIMS, New Delhi.