'How Tibetan people survive at high altitudes found'

The Tibetan people have inherited variants of five different genes that help them live at high altitudes, with one gene originating in the extinct human subspecies, the Denisovans, scientists have found.
The people of Tibet have survived on an extremely high and arid plateau for thousands of years, due to their amazing natural ability to withstand low levels of oxygen, extreme cold, exposure to ultraviolet (UV) light and very limited food sources.
Researchers, including those from University of Texas, Houston in the US, sequenced the whole genomes of 27 Tibetans and searched for advantageous genes.
The analysis identified two genes already known to be involved in adaptation to high altitude, EPAS1 and EGLN1, as well as two genes related to low oxygen levels, PTGIS and KCTD12.

They also picked out a variant of VDR, which plays a role in vitamin D metabolism and may help compensate for vitamin D deficiency, which commonly affects Tibetan nomads.
The Tibetan variant of the EPAS1 gene originally came from the archaic Denisovan people, but the researchers found no other genes related to high altitude with Denisovan roots.

Further analysis showed that Han Chinese and Tibetan subpopulations split as early as 44 to 58 thousand years ago, but that gene flow between the groups continued until about nine thousand years ago.
The study represents a comprehensive analysis of the demographic history of the Tibetan population and its adaptations to the challenges of living at high altitudes.

The results also provide a rich genomic resource of the Tibetan population, which will aid future genetic studies.
"The comprehensive analysis of whole-genome sequence data from Tibetans provides valuable insights into the genetic factors underlying this population's unique history and adaptive physiology at high altitude," said Tatum Simonson from University of California, San Diego in the US.
The study was published in the journal PLOS Genetics.