There are concerns the vaccine, which guards against four types of the HPV shown to cause cervical cancer and anogenital warts, may give girls a false sense of security about contracting sexually transmitted infections (STIs) and lead them to engage in riskier sexual activity.
"These findings suggest fears of increased risky sexual behaviour following HPV vaccination are unwarranted and should not be a barrier to vaccinating at a young age," said lead author on the study, Dr Leah Smith from Queen's University in Canada.
The researchers followed the girls until March 31 of their Grade 12 year.
About six per cent of girls became pregnant or contracted an STI between Grades 10 and 12, with 10,187 pregnancies and 6,259 cases of non-HPV-related sexually transmitted infections.
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"Neither HPV vaccination nor programme eligibility increased the risk of pregnancy nor non-HPV-related STIs among females aged 14-17 years," said Levesque, the senior author of the study.
Since 2006, the HPV vaccine has been licensed in almost 100 countries, including Canada. Many of these countries have national HPV vaccination programmes to protect young girls against the virus before they become sexually active.
The study was published in the Canadian Medical Association Journal.