"Their families have given somewhat similar accounts of policemen and personnel in black or dark blue uniforms and civilian clothes taking away their relatives," the HRCP said in a statement.
Activists - Raza Jarwar, Ali Ahmed Bughio, Shadi Khan Soomro and Abdul Aziz Gurghaiz - were abducted from their residences last week.
HRCP is "appalled" to learn of the near simultaneous abduction of four political activists from four different villages in Badin district," it said, adding that the "enforced disappearance is "alarming".