Europe's biggest bank aims to save up to USD 5.0 billion (4.4 billion euros) in annual costs within two and a half years as it seeks to boost profits and move past recent scandals that have scarred the British lender, including the rigging of foreign exchange markets.
HSBC said it wants to focus more on Asia, particularly in the Pearl River Delta region in southern China, amid an ongoing review of its London headquarters that will completed this year.
With regard to the group's possible new base, Gulliver said "there is an opportunity to create another Hong Kong" in Guangdong.
"The world is increasingly connected, with Asia expected to show high growth and become the centre of global trade over the next decade," he added.
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Philip Benton, an analyst at research group Euromonitor, said the bank was "redeploying their resources to where the most profit and the most revenue they can generate for the bank".
HSBC said there would be a 10-percent reduction in jobs with the shedding of between 22,000 and 25,000 positions worldwide.
A further 25,000 jobs would be lost with the sale of operations in Turkey and Brazil. However some or all of these staff could be kept on by potential buyers.
The announcements sent HSBC's share prices dropping 0.97 per cent to 613.50 pence in late deals on London's benchmark FTSE 100 index, which was down half a percent.
HSBC said the latest job losses would include between 7,000 and 8,000 positions in Britain -- where its retail bank is being relocated from London to Birmingham, central England, by 2019.