Ruffalo is currently in negotiations to reprise his role as Bruce Banner in "Thor: Ragnarok" alongside Chris Hemsworth, who plays the God of Thunder, reported Ace Showbiz.
The hammer-wielding hero and the Green Goliath have to face "what amounts to the Norse Apocalypse."
It will also feature a "distant planet" that's "not Asgard and not Earth."
Tom Hiddleston, who plays Loki, and Jaimie Alexander, who portrays Lady Sif, are expected to return to the franchise.
"Thor: Ragnarok" will be directed by Taika Waititi, whose credits include "Eagle vs Shark" and last year's "What We Do in the Shadows".