Wild cheetahs are down to under 10,000 from 100,000 a century ago with conventional wisdom blaming bigger predators for monopolising available food as their habitat becomes restricted, researchers said.
The traditional thinking has been that cheetahs no longer have sufficient access to prey to fuel their enormous energy output when engaging in super-fast chases.
In the first study of its kind, academics from Queen's University Belfast, other universities and conservation institutions have made the surprising discovery that, in the main, cheetahs do not use significantly more energy than other, similar-sized mammals.
So, where their prey have been reduced or re-distributed through human impacts, their ability to balance energy budgets has been severely curtailed.
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"We studied 19 free-roaming cheetahs each for two weeks across two sites in southern Africa, one in the Kalahari desert and the other in a wetter area," lead researcher Dr Michael Scantlebury from Queen's School of Biological Sciences said.
"We injected heavy water into the animals before tracking them continuously and collecting their faeces. From these samples, we could determine how much of this heavy water they were losing each day and calculate their energy expenditures.
"They can even withstand other species, such as lions and hyenas, stealing their prey. The reality may be that human activities - for example erecting fences that inhibit free travel or over-hunting cheetah prey - are forcing cheetahs to travel ever-increasing distances and that this may be compromising their energy more than any other single factor.
"Too often we blame lions and hyenas for decimating cheetah populations when in fact, it is likely to be us humans that drive their declines. Imagine how hard it must be for a small cub to follow its mother further and further through the desert to look for food, while she herself is fighting for survival," co-author Dr John Wilson of North Carolina State University said.
The study was published in the international journal Science.