The evacuees, who were "in urgent need of life-saving medical attention," according to the United Nations, were bussed out of their enclaves yesterday in a joint operation with the Syrian Arab Red Crescent.
In a carefully synchronised operation, they were all brought to a staging area in a rebel-held part of central Syria at dawn today before being transported on for treatment, the Syrian Observatory for Human Rights said.
Exactly 250 of the evacuees were brought out of the besieged rebel-held towns of Madaya and Zabadani, northwest of Damascus.
The Observatory said some of the pro-government evacuees were already beginning to arrive in the regime heartland province of Latakia on the Mediterranean coast.
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The evacuees from Madaya and Zabadani were being taken for
treatment in the rebel-held province of Idlib on the Turkish border.
The staging area at Qalaat al-Madiq, a medieval castle in central Hama province, has been used in similar evacuation operations in the past.
In December, rebels who quit the last opposition-held district of the central city of Homes were bussed out to Idlib province via Qalaat al-Madiq.
More than four million in Syria live in besieged or hard-to-reach areas, with limited or no access to food or medical supplies.
The UN has long pressed Damascus to grant unrestricted access to these areas, and has asked all sides to end sieges.
The dire humanitarian situation has been a major obstacle to progress in fragile peace talks in Geneva between the government and the opposition High Negotiations Committee.
Earlier this week, the HNC walked out of the talks, saying
More than 270,000 people have been killed in Syria since the conflict erupted in 2011.