The 35-year-old mother of one, who ended her five-year fashion line partnership with stylist Jeanne Yang, said now was the right time to cut ties, reported Us magazine.
"I loved every minute of my time working on Holmes & Yang. I remain passionate about the design aesthetic we created, and am so happy with what Jeanne and I accomplished.
"However I am now concentrating on acting and motherhood, which did not leave the label the time and attention it deserved. It is fantastic to feel like it's ending on a high," she said.